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The difference in drug release between GSH and DTT-treated samples emphasizes the selectivity of the system toward biologically relevant redox environments

102 Concurrent ROS overproduction and AGE deposition drive concentric left ventricular remodeling and myocardial stiffness, 103 whereas metabolic derangements (hyperglycemia, elevated free fatty acid (FFAs) and proinflammatory cytokines) exacerbate insulin resistance and impair angiogenesis

Dietary glutamate (Glu), an excitatory neurotransmitter, permeates CVOs and overwhelms inhibitory GABA neurotransmission, impeding release of specific hypothalamic hormones, including those causing low cortisol, low aldosterone, and low ADH with subsequent hypovolemia

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